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Signals Notebook records R&D experiments. Seal runs development, the lab, the batch and quality.

Seal, the GxP execution system, is your eBR, your QMS and more. Neil, your AI agent, does the paperwork across your systems. You sign. MiAlgae cut documentation time by 75%. Start with one process beside Revvity Signals Notebook.

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Where Signals Notebook falls short.

From Revvity’s own pages, support articles and announcements.

  • Signals Notebook
    R&D data management
    LIMS, ERP
    Through open APIs
    Batch records, CAPA
    Not on its product page
    Seal
    One set of records

    An R&D notebook, joined by APIs.

    Signals Notebook is an ELN for R&D, joined to LIMS and ERP through open APIs, and its product page names no batch records or CAPA. In Seal, the lab, the batch and quality are one set of records.

    Revvity Signals, Signals Notebook
  • Signals Notebook, in use
    Weeks
    Seal, a first process
    48 hours

    Weeks to begin.

    Revvity says most organisations can begin using Signals Notebook within weeks. Seal has a first process working for you to evaluate within 48 hours, once the scope is agreed and the inputs received.

    Revvity Signals, Signals Notebook
  • Notebook templates
    One
    The default template
    “Cannot be renamed or deleted”
    Who can edit it
    System administrators only
    Seal
    Record types your team changes

    One template for every notebook.

    Every Signals notebook uses one default template, which cannot be renamed or deleted, and only system administrators can edit it. In Seal, your team changes record types and steps, with selected tests on each change.

    Revvity Signals Support, May 2025
  • Signals AI
    Searches and acts on R&D data
    Where it runs
    Signals One, an upgrade
    Neil
    Drafts the change

    Its AI works on R&D data. Neil does the paperwork.

    Signals AI, announced in June 2026, lets scientists search and act on R&D data in natural language, inside the Signals One upgrade. Neil prepares the change itself and the paperwork around it, for your team to approve.

    Revvity, June 2026

See it in Seal.

Real Seal screens with fictional test data: a protocol, the experiment run from it, and a release test on the same records.

  1. 1

    A protocol, structured.

    PR-014 defines each parameter, keeps the calculation with its units, and says what it may be used for.

    Protocol PR-014, assay development, in Seal: a preparation instruction, a table of parameters with defined values and what each experiment records, the method reference and its intended use as a research comparison, not a released QC method.
    1. Units and calculation keptDilute to 2 mg/mL in 10 mL, with the calculation retained.
    2. Structured, not free textEach parameter with its defined value and what the experiment records.
    3. Its intended useResearch comparison; not a released QC method.
  2. 2

    The experiment, linked.

    EXP-043 links its protocol and reagent lot, keeps the instrument file, and is compared with earlier runs.

    Experiment EXP-043, incubation comparison, in Seal: linked protocol PR-014 and reagent lot RG-018, the recorded incubation time, relative signal and source file, and a table comparing it with runs EXP-041 and EXP-042.
    1. Linked to protocol and lotPR-014 and reagent lot RG-018, as records.
    2. Values with their source file30 minutes and 0.76 relative signal, from EXP-043-reader.csv.
    3. Runs comparedSame incubation, different reagent lots; cause not yet established.
  3. 3

    Each result with its method and source.

    Release test S-041-12: every result carries its method version, instrument file and limit, and the batch it came from.

    Sample S-041-12, release testing, in Seal: linked to batch B-041 and a potency preparation, a table of results for potency, impurity A and water content with unit, limit, status, method and source, and water content outside its limit with the investigation open.
    1. The batch it came fromB-041, linked to the sample.
    2. Method and source on every rowEach result keeps its method version, instrument file and limit.
    3. The exception, at the resultWater content 0.72% against ≤ 0.50%, with the investigation open.

What Seal’s customers measured.

Each figure links to the customer’s story.

QualityAcclinate and Skye Biologics

−50%
quality cycle times at Acclinate, from a procedure change to everyone trained.Acclinate
−40%
non-conformances at Skye Biologics, with training checked before execution.Skye Biologics

RecordsMiAlgae and Bioventix

−75%
documentation time at MiAlgae, from the lab to commercial production.MiAlgae
−80%
document admin time at Bioventix, after two decades on paper.Bioventix

Revvity Signals Notebook and Seal, side by side.

Every source is listed under References.

Signals NotebookSeal
What it isCloud-native SaaS ELN¹The GxP execution system: your eBR, your QMS and more
Built forR&D across industries¹Process development, the lab, manufacturing, batch release and quality
Data modelNotebooks, experiments, samples, tasks²Primitives your team composes: record types, their relationships, steps and checks
AISignals AI in Signals One: search and act on R&D data in natural language³Neil, Seal’s AI agent, prepares changes to the process; your team approves them
TemplatesOne notebook template; experiment and task templates by admins⁴⁵Record types and steps your team changes, with selected tests on each change
ReleasesTen a year; three for GxP use¹⁶Seal’s releases come with supplier evidence; your team assesses each against its intended use
QC and manufacturingLIMS and ERP via open APIs¹On the same records as the experiment
OwnerRevvity Signals Software, Inc.Opvia Ltd., trading as Seal
ChemistryNative ChemDraw, stoichiometry¹Samples and lots as linked records
Getting startedWeeks, Revvity says¹A 48-hour evaluation of one process, once the scope is agreed and the inputs received

Summary

The story
Revvity Signals Notebook is good for chemistry-led R&D. It began in 2017 as the ChemDraw E-Notebook bundled with ChemOffice, renamed Signals Notebook for ChemDraw: a personal web notebook with ChemDraw’s chemical intelligence built in.⁷ Nine years on, its core objects are notebooks, experiments, samples, and tasks and requests,² every notebook is built on one template that cannot be renamed or deleted,⁴ and only a system administrator can create or change task templates.⁵ Revvity says most organisations start within weeks,¹ yet for GxP work it offers three releases a year, staged a month apart so customers can test each one, with its own help through configuration, performance qualification and user acceptance testing.⁶ Its AI, Signals AI, announced in June 2026, lets scientists search and act on R&D data in natural language inside Signals One, which Revvity sells as an upgrade to the notebook.³¹ If chemists need a notebook with ChemDraw built in, it can work well. A process that is developed, tested, made and released needs more than a write-up.

1What Revvity Signals Notebook offers.

Signals Notebook is Revvity Signals Software’s cloud-native electronic lab notebook for R&D data management.¹ Revvity Signals, part of Revvity, says it builds on the legacy of CambridgeSoft and ChemDraw,⁸ and Revvity dates ChemDraw to 1985.⁹ The notebook began in 2017 as a personal web notebook bundled with ChemOffice, in which scientists wrote up research in notebooks and experiments.⁷ Today scientists document experiments with templates, rich text and embedded media and approve entries with electronic signatures; native ChemDraw automates stoichiometry and chemical search, inventory tracks chemicals, reagents and samples within the notebook, Signals DLX captures instrument data, and open APIs connect it to LIMS, ERP and other enterprise systems.¹ Administrators configure its system objects, from notebooks and experiments to samples and tasks and requests, in Signals Notebook System Configuration.² Signals One, which Revvity sells as an upgrade, adds AI-enhanced workflows, structured data handling and analytics on the notebook’s foundation.¹

2Running Seal alongside Signals Notebook.

Teams start Seal on one process while existing records stay where they are. Seal has no dedicated Revvity Signals connector. Where a system is not on Seal’s integrations list, Seal’s REST API reads and writes records from another system, and Scripts, versioned Python changed, tested and published like other Seal records, can call an external service after an event or on a schedule. Revvity offers open APIs for Signals Notebook.¹

Start with read access, such as bringing a development experiment’s results and reagent lots into the Seal record that needs them. Treat any write-back to Signals Notebook as a separate decision with defined actions, review gates and audit evidence. Agree identifiers and field mappings, test missing, delayed and duplicate records, reconcile what arrives against the source, and record which system is the source of truth. Instrument files can also reach Seal directly: the installable Seal IoT agent watches an export folder and uploads supported files to a configured Seal record.

3Moving from Signals Notebook to Seal.

Start with one protocol. Nothing else has to move first.

  1. Choose a template that is close to controlled use or changes often: a frequently repeated assay, a method approaching transfer or a calculation your team revises.
  2. Bring the protocol, a few representative runs and the files behind their results. Start with sample material, or arrange an NDA before sharing confidential records.
  3. Neil configures the protocol from your procedure: required inputs, units, calculations and sample and material links. Your scientists check it against the work. Once the scope is agreed and the inputs received, Seal prepares the first working process and its validation pack to evaluate within 48 hours. Production timing then depends on scope, interfaces, migration and your release requirements.
  4. Test a normal run, missing data, a deliberate variation and a changed calculation before you rely on it.
  5. If records move, scope exports, attachments, metadata, permissions and history first, map reusable fields, preserve the source records and keep gaps visible.

Retention obligations continue for the records that stay in Signals Notebook. The regulatory guide sets out how Seal keeps validation evidence with each version.

References

  1. 1Signals Notebook, Revvity Signals Software, archived 5 October 2026. https://web.archive.org/web/20261005180912/https://revvitysignals.com/products/research/signals-notebook-eln (read 5 November 2026)
  2. 2Signals Notebook: Understanding and Managing System Objects in Signals Notebook, Revvity Signals Support. https://support.revvitysignals.com/hc/en-us/articles/37318880077844-Signals-Notebook-Understanding-and-Managing-System-Objects-in-Signals-Notebook (read 5 November 2026)
  3. 3Revvity Launches Signals AI, a Native Agentic Framework for Accelerating Scientific R&D, Revvity, 22 June 2026. https://s202.q4cdn.com/560601150/files/doc_news/Revvity-Launches-Signals-AI-a-Native-Agentic-Framework-for-Accelerating-Scientific-RD-2026.pdf (read 5 November 2026)
  4. 4Signals Notebook: Understanding and Configuring the Default Notebook Template, Revvity Signals Support. https://support.revvitysignals.com/hc/en-us/articles/37320420726676-Signals-Notebook-Understanding-and-Configuring-the-Default-Notebook-Template (read 5 November 2026)
  5. 5Signals Notebook: Why only System Admins can create Task Templates, Revvity Signals Support, 5 October 2026. https://support.revvitysignals.com/hc/en-us/articles/54181312596628-Signals-Notebook-Why-only-System-Admins-can-create-Task-Templates (read 5 November 2026)
  6. 6Validation Readiness, Revvity Signals Software, archived 20 May 2026. https://web.archive.org/web/20260520185029/https://revvitysignals.com/validation-readiness (read 5 November 2026)
  7. 7ChemOffice 16 release update – Now includes SignalsNotebook, Revvity Signals Support, 13 March 2017. https://support.revvitysignals.com/hc/en-us/articles/4408268559380-ChemOffice-16-release-update-Now-includes-SignalsNotebook (read 5 November 2026)
  8. 8About Us, Revvity Signals Software, archived 5 October 2026. https://web.archive.org/web/20261005230147/https://revvitysignals.com/company/about-us (read 5 November 2026)
  9. 9Chemicals & Materials Solutions, Revvity Signals Software, archived 6 May 2026. https://web.archive.org/web/20260506110828/https://revvitysignals.com/solutions/chemicals-and-materials (read 5 November 2026)

AQuestions and answers

Is Seal better than Revvity Signals Notebook?

Yes. Revvity Signals Notebook is good for chemistry-led R&D. It began in 2017 as the ChemDraw E-Notebook bundled with ChemOffice, renamed Signals Notebook for ChemDraw: a personal web notebook with ChemDraw’s chemical intelligence built in. Nine years on, its core objects are notebooks, experiments, samples, and tasks and requests, every notebook is built on one template that cannot be renamed or deleted, and only a system administrator can create or change task templates. Revvity says most organisations start within weeks, yet for GxP work it offers three releases a year, staged a month apart so customers can test each one, with its own help through configuration, performance qualification and user acceptance testing. Its AI, Signals AI, announced in June 2026, lets scientists search and act on R&D data in natural language inside Signals One, which Revvity sells as an upgrade to the notebook. If chemists need a notebook with ChemDraw built in, it can work well. A process that is developed, tested, made and released needs more than a write-up. Seal has no fixed model of one kind of work. It is built from primitives: record types, the relationships between them, and the steps and checks that use them, which your own team composes into your process, with Neil able to prepare each change for approval. So one platform runs process development, the laboratory, manufacturing, batch release and the quality system, and each change becomes a new version, released once its selected tests pass, while earlier runs keep theirs. Moving from paper, MiAlgae cut documentation time by 75% and went from the laboratory to commercial production on one platform.

Is Seal an alternative to Revvity Signals Notebook?

Yes. Signals Notebook is designed for R&D. Seal is a structured ELN on the same platform as QC testing, batch records and the quality system, and each change your team makes to a protocol or calculation is released with its acceptance tests. Signals Notebook connects to a separate LIMS through open APIs. Teams usually start Seal on one protocol.

Who makes Signals Notebook?

Revvity Signals Software, Inc., part of Revvity. Signals Notebook is its cloud-native lab notebook for R&D, powered by ChemDraw. It began in 2017 as a personal web notebook bundled with ChemOffice.

Does Signals Notebook run QC testing and batch records?

Signals Notebook is designed for R&D. Revvity connects it to LIMS, ERP and other enterprise systems through open APIs, and its product page names no batch records, deviations or CAPA. Revvity’s newest answer to the hand-off, Signals LabGistics, announced in October 2026, is a separate orchestration layer designed to work within existing laboratory and manufacturing platforms. In Seal, QC testing, batch records and quality run on the same records as the experiment.

How does Signals Notebook’s AI compare with Neil?

Revvity’s Signals AI, announced in June 2026, is built into Signals One, which Revvity sells as an upgrade to Signals Notebook. Revvity says it lets scientists search, ask about and act on connected R&D data in natural language, with interactive views of molecules, sequences and experimental results. Neil prepares changes to the process itself, the protocols, calculations and workflows in Seal’s configuration, for your team to verify and approve. In line with the EU’s draft GMP Annex 22 on AI, Neil is not used in GMP execution.

Can Seal work alongside Signals Notebook?

Yes, and that is a low-risk way to start. Seal has no dedicated Revvity connector, but its REST API and Scripts can connect a system that is not on its integrations list, and Revvity provides open APIs for Signals Notebook. Start with read access and agree which system is the source of truth for each record.

How long does it take to start with Seal?

Once the scope is agreed and the inputs received, Seal prepares a first working process and its validation pack to evaluate within 48 hours, configured from one of your protocols or procedures. Production timing then depends on scope, interfaces, migration and your release requirements.

Start beside Revvity Signals Notebook.

Start with one template that changes often or is close to controlled use. Seal reads what it needs from Signals Notebook through its REST API and Scripts, so nothing has to move on day one.

Book a demo