All blueprints

Instrument data. Connected to the work.

Capture instrument files with Seal Edge. Keep the originals, metadata and review history connected to the sample, batch or investigation in Seal.

Illustration of a seal following a sample vial to an analytical instrument and its result.
On your site Windows or macOS
Instrument workstationVendor software exports
Raw dataMethodSequenceAudit trail
Local folder or accessible network share
Seal EdgeInstallable capture agent
  1. Watch the chosen folder
  2. Wait for file-size stability
  3. Run the configured script
  4. Upload to a Seal record
Run history and connection diagnostics
Outbound
HTTPS
File-upload path
In Seal
Scientific data recordOriginal file attached to the configured template
Source and acquisitionSample and methodCompleteness and review
Connected to the workLab, manufacturing and qualityContext for people and neil
The folder-capture route does not require inbound ports.Capture rules, metadata mapping and review requirements are configured for the source.

An instrument produces files. The lab needs a result. Manufacturing needs to know which batch it informs. Quality needs the evidence behind the decision. Seal connects that work in one platform, with the original scientific data still available to inspect.

Install Seal Edge. Connect the instruments you already use.

Seal Edge is the installable agent that connects local instrument output to Seal. Run it on a Windows or macOS machine with access to the source files: an instrument workstation, a local staging machine or a host that can read the relevant network share. Existing installation materials call the agent Seal IoT Bridge.

Choose the folder, whether to include subfolders and which Seal template should receive the files. A file-watch trigger detects new or changed files, waits for file-size stability and runs a configurable script to upload the file as an attachment to a record. Different sources can use different triggers and templates.

This makes the connection adaptable to the laboratory. The vendor application continues to acquire the data; Edge bridges its supported exports into the workflows your team runs in Seal. Preserving a proprietary file and interpreting its contents are separate capabilities. Agree and verify the required formats, extraction and mappings for each source.

What IT needs to know

The documented folder-upload route uses outbound HTTPS on port 443 and does not require inbound ports. The running account needs access to the watched folder; Windows network shares use that account’s permissions. For unattended operation, configure a dedicated account and the host’s startup arrangement.

Scope the destination workspace and API credentials, and test connectivity from the actual host. Authentication and agent updates require additional service domains, not only seal.run. Review the full allowlist, update behaviour and operating responsibilities before deployment.

What happens when capture is interrupted

The agent exposes connection diagnostics, recent runs and errors. Upload scripts can retry transient failures. Startup capture can include files already present, so files that arrived while the agent was stopped can be picked up if they remain at the source.

That recovery needs an agreed source-retention window and reconciliation rules. A changed file can trigger another upload; the basic folder-to-record script does not deduplicate by filename. Define how acquisition identity, retries and changed content are handled before treating the connection as ready for use.

Start with neil. Keep the evidence behind the answer.

Ask which acquisitions support a batch, what changed between two reports or where an investigation is missing evidence. neil can follow accessible records, connect the findings and help prepare the next step. Your team can inspect the sources and review the conclusion.

That starts with usable context: the sample, instrument, method, acquisition and version. Unsupported formats, missing records and unresolved matches need to remain visible—not become confident guesses.

Capture the acquisition, not just the report.

A chromatographic run may produce raw data, a method, a sequence, an audit trail and a report. Define the required file roles for the source. A finished PDF does not prove that the rest arrived.

Configure capture around the supported interface: an export, watched location or API. Account for files still being written, late companion files, duplicate transfers and interrupted connections. A missing file and a checksum mismatch require different responses.

Preserve the original bytes and their source metadata. Record capture time separately from acquisition time, and keep the source identity behind any normalised timestamp. Extracted values carry their parser and version so reviewers can trace them back to the file.

ACQ-1842 / HPLC-04Sample acquisition

Raw acquisition

sequence-1842.raw

Source measurements
Received

Method

assay-method-v08.xml

Acquisition settings
Received

Sequence

sequence-1842.csv

Sample and injection order
Received

Audit trail

audit-1842.xml

Actions and changes
Missing

3 of 4 required files received

The PDF report cannot stand in for the missing audit trail. Keep the package incomplete.

One platform from acquisition to investigation.

Scientific data sits alongside lab workflows, electronic lab notebooks, manufacturing and quality management in Seal. The acquisition links to a sample; the sample links to a batch; an investigation points to the evidence it assesses.

Those relationships give people and neil a common context. They distinguish an original file from a processed result, an approved report from a draft and a complete package from one still waiting for review.

One acquisition. A shared chain of evidence.Sample record relationships
Original acquisitionACQ-1842
Native dataMethod v08Audit trail
Source files remain attached
LaboratorySample QC-1842Test, method and reviewed result
ManufacturingBatch B-041The operation the result informs
QualityInvestigation DEV-018Findings, evidence and decision
“Which evidence supports this batch?”neil follows the linked records the requester can access. The source, version and review state stay visible.

You do not have to replace every system to start. Connect the source needed for the first job, agree which system owns each record and verify the mapping. Review ambiguous matches rather than silently attaching a result to the wrong sample.

A new result must not erase the old one.

Reprocessing, reintegration and report generation create derived records. Keep the input objects, method and software version, changed parameters, reason and output together. Reviewers should be able to compare the earlier result with the new one and reach the same preserved acquisition from either.

Review covers the source evidence and the changes, not only the final number. Findings, responses and required signatures belong to the package being assessed. neil can assist with the investigation; it does not turn receipt of a file into approval of a result.

Evolve the connection under change control.

A software upgrade can change a file format. A new method can add a companion file. A parser update can change an extracted value. Treat these as controlled configuration changes, with affected requirements, specifications and verification linked to the version that will enter use.

Seal’s continuous validation approach keeps that work in the platform. Verify representative inputs and failure cases, review the impact and approve the change. Keep existing records connected to the configuration and processing history that produced them.

For an Edge connection, the change scope includes the agent version, trigger script, source path, destination template and metadata mappings. Keep the relevant user requirements, functional and design specifications, configuration specification and verification evidence linked to the change. Repeat the affected checks when the configuration changes; investigate exceptions before release. Installation alone does not validate the end-to-end workflow.

Retrieve the evidence when it matters.

Search by the work you recognise: sample, batch, method, instrument or investigation. Confirm why a record matched and whether it is the original, a derived result or a report. Access permissions still apply to search, neil and export.

Retention is specific to the record and its governing policy—not a universal number of years. Define the start event, policy version, holds and disposition authority. Test restore and readability with the required files and applications; storing a binary is not the same as being able to review it later.

For an inspection or migration, keep the selected objects, manifest, identity mapping and verification evidence together. Clearly distinguish a migrated rendition from a native original.

Prove one source before expanding.

Bring one representative acquisition and the question or workflow it needs to support. Confirm the vendor interface, file formats, required companions, ownership and review expectations. Start with a sample, or arrange an NDA before sharing confidential records.

Include a late file, a duplicate transfer, a clock discrepancy and a failed integrity check in the evaluation. Demonstrate the path from capture to retrieval, including what happens when the expected evidence is absent. Then extend the pattern to the next instrument or laboratory.

Operating model

Configured in Seal, with shared records across the work.

Capabilities

Connected records

Entity hierarchy
What it records
Kind
Scientific Data Source
Instrument or application, version, workstation, interface, formats, identities, clock, owner, and state.
entity
Scientific Capture Rule
Trigger, source, expected files, quiescence, retries, duplicates, parsing, quarantine, and notification.
entity
Chromatography File-Set Capture
Sequence, method, raw, audit, result and report files with completeness, retry and quarantine rules.
template
CAPTURE-HPLC-LAB04-v08
Production rule for validated chromatography workstations in laboratory 04.
record
Scientific Data Package
Acquisition identity, expected roles, original files, completeness, metadata, context, review, and state.
entity
Instrument Acquisition Package
Original acquisition and companion files, metadata, sample context, completeness, review, and retention.
template
ACQ-HPLC04-20260803-1842
Complete assay sequence after recovery of one late audit file.
record
Scientific Data Object
Binary, name, format, size, timestamps, checksum, source, capture, storage, and preservation state.
entity
Scientific Metadata
Property, value, unit, source location, parser, parser version, confidence, review, and version.
entity
Scientific Work Context
Sample, test, batch, study, method, instrument, analyst, result, investigation, and matching evidence.
entity
Scientific User Identity
Local and directory accounts, roles, mappings, service use, validity, review, and deactivation.
entity
Scientific Data Review
Risk rule, package, source data, metadata, audit, changes, findings, resolution, signature, and state.
entity
Risk-Based Scientific Data Review
Required source files, changes, reprocessing, audit events, findings, resolution, and approval.
template
SDR-ACQ1842-v02
Approved review including a justified reintegration and clock-offset assessment.
record
Derived Scientific Data
Source objects, operation, application, version, parameters, operator, output, checksum, and review.
entity
Approved Instrument Report
Original inputs, application, method, processing parameters, output, checksum, reviewer, and signature.
template
REPORT-ACQ1842-v03
Final signed rendition generated after approved reintegration.
record
Scientific Audit Event
Actor, time, source, object, action, before and after, reason, context, review, and disposition.
entity
Scientific Search Index
Object, metadata, context, content, parser, version, indexing state, errors, and matched fields.
entity
Scientific Retention Schedule
Record class, governing context, start event, policy, due date, holds, disposition, and state.
entity

Questions and answers

An SDMS manages scientific files and their provenance: acquisition, capture, processing, review and retention. A LIMS manages laboratory work such as samples, tests and results. Seal connects both in one platform, so the result stays linked to its original instrument evidence.
Support depends on the vendor, software version, available export or API and required file roles. We assess a representative acquisition before agreeing the connection. Preserving a proprietary binary does not imply that Seal or neil can interpret it; metadata extraction and readable renditions must be verified for that format.
On a Windows or macOS host with access to the instrument output. This may be the workstation, a staging machine or a host with access to a network share. The running account needs the relevant folder permissions. The existing installation guide uses the name Seal IoT Bridge; the agent’s folder triggers and scripts connect files to records in Seal.
Not necessarily. One host can run multiple folder triggers if its account can access the relevant sources. The documented folder-upload route uses outbound HTTPS without inbound ports. Agree network boundaries and source access with IT; include authentication and update services in the outbound allowlist, not just seal.run.
Files must remain available at the source. The agent can be configured to process files already present when it starts, and upload scripts can retry transient failures. Agree the source-retention window and reconcile missed, repeated and changed files. The basic folder-to-record script does not automatically deduplicate by filename, so replay behaviour must be configured and verified.
The capture rule defines expected file roles and how writing completion is detected. A package remains incomplete while required evidence is missing. Retries must preserve acquisition identity; checksum conflicts and duplicates need explicit reconciliation. The evaluation should demonstrate each case on the proposed interface.
A report can be useful for review, but may not include the native acquisition, sequence, method, processing parameters or audit trail. Define the evidence required for the intended use and retain those objects with their roles. Do not present a rendition as the native original.
neil can work with accessible records and supported representations: find related acquisitions, compare recorded metadata and help assemble evidence for an investigation. Missing files, unsupported formats and uncertain matches must remain explicit. Your team evaluates the findings and controls decisions and release.
Keep the original acquisition and create a related derived record. Retain the inputs, method, parameters, application version, operator, time and reason, along with the output and its review. Earlier results remain available; a later report does not erase the processing history.
Assess the affected formats, fields, mappings and downstream workflows. Update the configuration and its specifications, then verify representative acquisitions and failure cases. Retain results and approvals against the changed version. Existing records keep their original provenance and processing history.
Agree retention by record class, governing event and applicable policy. Track active holds separately from retention dates. A restore test should recover the required objects, verify integrity and demonstrate readability using the necessary formats and applications. There is no single retention period appropriate to every acquisition.
Scope the source inventory, native files, renditions and missing evidence first. Verify identity mappings, file integrity and sample or batch relationships, and retain exceptions and migration evidence. Label a legacy PDF as a rendition when the native source is unavailable; do not imply that the missing original was recovered.
One representative acquisition, its source software and interface, the expected file set and a question or workflow to support. Agree owners, access, review and retention needs. Test late and duplicate files, interrupted transfers, integrity exceptions and retrieval before expanding to more sources.

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